for Developmental (Epi)Genomics
In eukaryotes, the complex regulation of temporal- and tissue-specific gene expression is controlled by the binding of transcription factors to enhancers, which in turn interact with the promoter of their target gene(s) via the formation of a chromatin loop. Despite their importance, the properties governing enhancer function and enhancer-promoter loops in the context of the three-dimensional organization of the genome are still poorly understood.
In this context, my group will apply an interdisciplinary approach, combining state-of-the-art methods in genetics, genomics, and computational biology, including novel single-cell techniques, using Drosophila embryogenesis as a model system. Our results will provide a unique view of the functionality of enhancer-promoter interactions in a developing embryo, a significant step towards understanding the link between chromatin organization and transcription regulation.
09/2017 The lab is now funded by the ERC Starting grant!
07/2017 The lab is now funded by the ATIP-Avenir program!
12/2016 We are hiring! Come join this new adventure :) More info.
12/2016 The lab is now funded by the Fondation pour la Recherche Médicale "Amorçage de Jeunes équipes" program! Stay tuned for job offers to come.
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Institut de Génomique Fonctionnelle de Lyon (IGFL)
ENS de Lyon - CNRS UMR 5242 - INRA USC 1370
32-34 avenue Tony Garnier, 69007 Lyon, France